Generic costs have been going down but many patients are paying more for these medicines. That doesn’t add up.

This contradiction reflects markups all along the supply chain and games being played by brand name drug companies and middlemen who are subverting the savings power of generic medicines.

This is counter to the intent of Congress when it established the modern generics industry 35 years ago.

At a time when some in the pharmaceutical ecosystem are fighting to keep their prices hidden from view, the generic and biosimilar industry wants patients and policymakers to understand the costs of its medicines when they leave the manufacturer and begin their journey to the consumer.

Generic Cost Vs. Brand Cost – Top 100 Drugs by Sales Volume 2018


GENERIC
DRUG
COSTBRAND-NAME
DRUG
COST
polyethylene glycol $0.02 Miralax N/A 
metformin $0.09 Glucophage $1.06 
gabapentin $0.08 Neurontin $4.52 
metoprolol $0.09 Toprol-Xl $1.06 
atorvastatin $0.09 Lipitor $7.39 
lisinopril $0.02 Zestril $4.41 
acetaminophen/hydrocodone $0.10 Acetaminophen Hydrocodone N/A 
amlodipine $0.02 Norvasc $5.90 
omeprazole $0.11 Prilosec $9.08 
lactulose $0.02 Chronulac N/A 
amoxicillin $0.03 Amoxil N/A 
carvedilol $0.05 Coreg $6.91 
losartan $0.04 Cozaar $3.76 
furosemide $0.05 Lasix $0.78 
tramadol $0.04 Ultram $3.00 
simvastatin $0.03 Zocor $6.99 
alprazolam $0.03 Xanax $5.75 
ranitidine $0.09 Zantac $5.90 
hydrochlorothiazide $0.01 Hydrodiuril N/A 
sertraline $0.05 Zoloft $9.57 
ibuprofen $0.04 Motrin $0.14 
naproxen $0.12 Ec-Naprosyn $5.95 
diphenhydramine $0.03 Benadryl N/A 
pantoprazole $0.07 Protonix $6.97 
acetaminophen/oxycodone $0.17 Percocet $18.16 
bupropion $0.32 Wellbutrin $30.19 
trazodone $0.07 Oleptro N/A 
triamcinolone acetonide $0.08 Aristocort N/A 
cetirizine $0.06 Zyrtec N/A 
levetiracetam $0.11 Keppra $5.59 
montelukast $0.11 Singulair $7.02 
fluoxetine $0.14 Sarafem $18.03 
escitalopram $0.07 Lexapro $10.14 
clonazepam $0.04 Klonopin $2.62 
tamsulosin $0.08 Flomax $2.21 
albuterol/ipratropium $0.09 Combivent $86.09 
metronidazole $0.04 Flagyl $3.27 
glipizide $0.07 Glucotrol $0.98 
rosuvastatin $0.09 Crestor $7.57 
pravastatin $0.11 Pravachol $4.50 
duloxetine $0.26 Cymbalta $7.58 
lorazepam $0.05 Ativan $19.03 
hydroxyzine $0.06 Vistaril $2.61 
meloxicam $0.02 Mobic $7.09 
cephalexin $0.08 Keflex $8.55 
hydrochlorothiazide/lisinopril $0.03 Prinzide $5.53 
atenolol $0.05 Tenormin $9.28 
cyclobenzaprine $0.08 Flexeril $0.98 
venlafaxine $0.29 Effexor $11.89 
citalopram $0.03 Celexa $8.27 
buspirone $0.08 Buspar N/A 
amoxicillin/clavulanic acid $0.19 Augmentin $4.98 
allopurinol $0.11 Zyloprim $1.82 
clopidogrel $0.11 Plavix $6.21 
lamotrigine $0.20 Lamictal $15.80 
topiramate $0.62 Topamax $11.32 
ethinylestradiol/norgestimate $0.42 Ortho-Tricyclen $0.89 
folic acid $0.04 Folic Acid N/A 
zolpidem $0.07 Ambien $16.09 
clonidine $0.10 Catapres $25.70 
hydrochlorothiazide/losartan $0.06 Hyzaar $4.76 
ciprofloxacin $0.06 Cipro $1.38 
quetiapine $0.16 Seroquel $13.20 
hydrocortisone $0.14 Solu-Cortef N/A 
hydralazine $0.05 Apresoline N/A 
tizanidine $0.12 Zanaflex $2.55 
warfarin $0.10 Coumadin $1.40 
spironolactone $0.12 Aldactone $2.90 
divalproex $0.28 Depakote $3.27 
diltiazem $0.36 Dilacor  $6.64 
famotidine $0.11 Pepcid $12.94 
guaifenesin $0.10 Mucinex N/A 
baclofen $0.12 Lioresal N/A 
ammonium $0.05 Lac-hydrin N/A 
nystatin $0.13 Mycostatin N/A 
propranolol $0.23 Inderal $44.13 
carbidopa/levodopa $0.32 Sinemet $1.37 
glimepiride $0.06 Amaryl $2.83 
fluticasone $0.33 Flonase $13.01 
dextromethorphan/promethazine $0.01 Phenergan DM N/A 
ondansetron $0.19 Zofran $26.91 
ketoconazole $0.21 Nizoral Shampoo $0.30 
loperamide $0.08 Imodium N/A 
amitriptyline $0.14 Elavil N/A 
sulfamethoxazole/trimethoprim $0.09 Bactrim $2.35 
clindamycin $0.15 Cleocin T $0.39 
propofol $0.16 Diprivan N/A 
doxycycline $0.51 Vibramycin $1.14 
fenofibrate $0.53 Tricor $0.27 
diclofenac $0.21 Zorvolex $0.52 
ethinylestradiol/ levonorgestrel $0.36 Ortho-Tricyclen N/A 
paroxetine $0.20 Paxil $3.29 
esomeprazole $0.38 Nexium $7.61 
morphine $0.46 Morphine N/A 
heparin $0.34 Heparin N/A 
finasteride $0.09 Propecia $3.37 
promethazine $0.06 Phenergan N/A 
codeine/promethazine $0.02 Phenergan Codeine N/A 
hydrochlorothiazide/triamterene $0.08 Dyazide $1.99 
dicyclomine $0.11 Bentyl $0.51 

GENERIC DRUGCOSTBRAND-NAME DRUGCOST
polyethylene glycol $0.02 Miralax N/A 
metformin $0.09 Glucophage $1.06 
gabapentin $0.08 Neurontin $4.52 
metoprolol $0.09 Toprol-Xl $1.06 
atorvastatin $0.09 Lipitor $7.39 
lisinopril $0.02 Zestril $4.41 
acetaminophen/hydrocodone $0.10 Acetaminophen Hydrocodone N/A 
amlodipine $0.02 Norvasc $5.90 
omeprazole $0.11 Prilosec $9.08 
lactulose $0.02 Chronulac N/A 
amoxicillin $0.03 Amoxil N/A 
carvedilol $0.05 Coreg $6.91 
losartan $0.04 Cozaar $3.76 
furosemide $0.05 Lasix $0.78 
tramadol $0.04 Ultram $3.00 
simvastatin $0.03 Zocor $6.99 
alprazolam $0.03 Xanax $5.75 
ranitidine $0.09 Zantac $5.90 
hydrochlorothiazide $0.01 Hydrodiuril N/A 
sertraline $0.05 Zoloft $9.57 
ibuprofen $0.04 Motrin $0.14 
naproxen $0.12 Ec-Naprosyn $5.95 
diphenhydramine $0.03 Benadryl N/A 
pantoprazole $0.07 Protonix $6.97 
acetaminophen/oxycodone $0.17 Percocet $18.16 
bupropion $0.32 Wellbutrin $30.19 
trazodone $0.07 Oleptro N/A 
triamcinolone acetonide $0.08 Aristocort N/A 
cetirizine $0.06 Zyrtec N/A 
levetiracetam $0.11 Keppra $5.59 
montelukast $0.11 Singulair $7.02 
fluoxetine $0.14 Sarafem $18.03 
escitalopram $0.07 Lexapro $10.14 
clonazepam $0.04 Klonopin $2.62 
tamsulosin $0.08 Flomax $2.21 
albuterol/ipratropium $0.09 Combivent $86.09 
metronidazole $0.04 Flagyl $3.27 
glipizide $0.07 Glucotrol $0.98 
rosuvastatin $0.09 Crestor $7.57 
pravastatin $0.11 Pravachol $4.50 
duloxetine $0.26 Cymbalta $7.58 
lorazepam $0.05 Ativan $19.03 
hydroxyzine $0.06 Vistaril $2.61 
meloxicam $0.02 Mobic $7.09 
cephalexin $0.08 Keflex $8.55 
hydrochlorothiazide/lisinopril $0.03 Prinzide $5.53 
atenolol $0.05 Tenormin $9.28 
cyclobenzaprine $0.08 Flexeril $0.98 
venlafaxine $0.29 Effexor $11.89 
citalopram $0.03 Celexa $8.27 
buspirone $0.08 Buspar N/A 
amoxicillin/clavulanic acid $0.19 Augmentin $4.98 
allopurinol $0.11 Zyloprim $1.82 
clopidogrel $0.11 Plavix $6.21 
lamotrigine $0.20 Lamictal $15.80 
topiramate $0.62 Topamax $11.32 
ethinylestradiol/norgestimate $0.42 Ortho-Tricyclen $0.89 
folic acid $0.04 Folic Acid N/A 
zolpidem $0.07 Ambien $16.09 
clonidine $0.10 Catapres $25.70 
hydrochlorothiazide/losartan $0.06 Hyzaar $4.76 
ciprofloxacin $0.06 Cipro $1.38 
quetiapine $0.16 Seroquel $13.20 
hydrocortisone $0.14 Solu-Cortef N/A 
hydralazine $0.05 Apresoline N/A 
tizanidine $0.12 Zanaflex $2.55 
warfarin $0.10 Coumadin $1.40 
spironolactone $0.12 Aldactone $2.90 
divalproex $0.28 Depakote $3.27 
diltiazem $0.36 Dilacor  $6.64 
famotidine $0.11 Pepcid $12.94 
guaifenesin $0.10 Mucinex N/A 
baclofen $0.12 Lioresal N/A 
ammonium $0.05 Lac-hydrin N/A 
nystatin $0.13 Mycostatin N/A 
propranolol $0.23 Inderal $44.13 
carbidopa/levodopa $0.32 Sinemet $1.37 
glimepiride $0.06 Amaryl $2.83 
fluticasone $0.33 Flonase $13.01 
dextromethorphan/promethazine $0.01 Phenergan DM N/A 
ondansetron $0.19 Zofran $26.91 
ketoconazole $0.21 Nizoral Shampoo $0.30 
loperamide $0.08 Imodium N/A 
amitriptyline $0.14 Elavil N/A 
sulfamethoxazole/trimethoprim $0.09 Bactrim $2.35 
clindamycin $0.15 Cleocin T $0.39 
propofol $0.16 Diprivan N/A 
doxycycline $0.51 Vibramycin $1.14 
fenofibrate $0.53 Tricor $0.27 
diclofenac $0.21 Zorvolex $0.52 
ethinylestradiol/ levonorgestrel $0.36 Ortho-Tricyclen N/A 
paroxetine $0.20 Paxil $3.29 
esomeprazole $0.38 Nexium $7.61 
morphine $0.46 Morphine N/A 
heparin $0.34 Heparin N/A 
finasteride $0.09 Propecia $3.37 
promethazine $0.06 Phenergan N/A 
codeine/promethazine $0.02 Phenergan Codeine N/A 
hydrochlorothiazide/triamterene $0.08 Dyazide $1.99 
dicyclomine $0.11 Bentyl $0.51 

The prices in this chart reflect the list price from a manufacturer to a wholesaler or a direct purchaser without any discounts or rebates a/k/a Wholesale Acquisition Costs (WAC).